Producción Académica

INTERESES CLÍNICOS

Neurocirugía Funcional y Estereotáxica, Neuromodulación, Parkinson, Distonía, Temblor esencial, Espasticidad, Dolor, Epilepsia, Radiocirugía, Cirugía de base de Cráneo, Cirugía de Columna, Cirugía Mínimamente invasiva, Endoscopia Cerebral y Espinal, Fetoscopia.

INTERESES EXPERIMENTALES

Neuromodulación, Robótica, Transplante neuronal, Clonación y Bioingeniería. Realiza investigación en DBS (estimulación cerebral profunda), VBS (Estimulación Cerebral Visual), ABS (estimulación auditiva del cerebro), BWE (Brainwave Entrainment), Realidad virtual y de aumentada, así como Neurogaming (Video juegos).

Artículos en Pubmed: 37
Capítulos de libro: 3
Citaciones: 277
Índice H: 10
Índice i10: 10
Editor científico: BMC Cancer; Clinical Neurology & Neurosurgery; Journal of Psychotherapy and Psychological Disorders.
Co-autor página de Internet: www.pubneuro.com
Creador de la Aplicación: Parkinsounds en colaboración con TEVA y Spotify.
Patentes: Patente de Modelo de Utilidad No. 12 169719, Resolución No. 4221 de 10/02/2015. Dispositivo auditivo y visual externo rítmico en forma de gafas para controlar la marcha en pacientes con Parkinson.

PUBLICACIONES

A lo largo de su carrera, Dr. WO, ha sido un faro de innovación y creatividad. Su trabajo ha influido significativamente en la forma en que entendemos el funcionamiento del cerebro y el sistema nervioso central. Ha desarrollado numerosas publicaciones, investigaciones y artículos científicos que han sido citados por académicos de todo el mundo.

Optimizing microdialysis for deep brain stimulation. Lopez WO, Fonoff ET, Hamani C, Tierney TS, Alho E, Ghilardi MG, Teixeira MJ, Martinez RC. Front Biosci (Elite Ed). 2016 Jan 1;8:299-310. doi: 10.2741/E768. PMID: 26709663 Review.

Safety and Feasibility of Nucleus Accumbens Surgery for Drug Addiction: A Systematic Review. Navarro PA, Paranhos T, Lovo E, De Oliveira-Souza R, Gorgulho AA, De Salles A, López WOC. Neuromodulation. 2021 Jan 18. doi: 10.1111/ner.13348. Online ahead of print. PMID: 33460201 Review.

Clinical neurotransplantation protocol for Huntington’s and Parkinson’s disease. Lopez WO, Nikkhah G, Kahlert UD, Maciaczyk D, Bogiel T, Moellers S, Schültke E, Döbrössy M, Maciaczyk J. Restor Neurol Neurosci. 2013;31(5):579-95. doi: 10.3233/RNN-130317. PMID: 23777636 Review.

Evolution of Movement Disorders Surgery Leading to Contemporary Focused Ultrasound Therapy for Tremor. Ahmed H, Field W, Hayes MT, Lopez WO, McDannold N, Mukundan S Jr, Tierney TS. Magn Reson Imaging Clin N Am. 2015 Nov;23(4):515-22. doi: 10.1016/j.mric.2015.05.008. Epub 2015 Jul 11. PMID: 26499271 Free PMC article. Review.

Hypertrophic Olivary Degeneration: A Neurosurgical Point of View. Carvalho CH, Kimmig H, Lopez WO, Lange M, Oeckler R. J Neurol Surg A Cent Eur Neurosurg. 2016 Jan;77(1):59-62. doi: 10.1055/s-0035-1566114. Epub 2015 Nov 20. PMID: 26588253 Review.

Neurosurgical treatment for dystonia: long-term outcome in a case series of 80 patients. Martínez JA, Pinsker MO, Arango GJ, Garcia X, Oscar AE, Furlanetti L, Reithmeier T, Aranda IA, Marin JH, Lopez WO.Clin Neurol Neurosurg. 2014 Aug;123:191-8. doi: 10.1016/j.clineuro.2014.05.012. Epub 2014 May 29.PMID: 24995965.

Lead Poisoning: Myoclonus Following Welding Exposure. Cury RG, Marin JH, Contreras Lopez WO. Acta Med Port. 2017 Dec 29;30(12):889. doi: 10.20344/amp.9398. Epub 2017 Dec 29. PMID: 29364803.

Effectiveness of Deep Brain Stimulation in Reducing Body Mass Index and Weight: A Systematic Review. Contreras López WO, Navarro PA, Crispín S. Stereotact Funct Neurosurg. 2021 Sep 28:1-11. doi: 10.1159/000519158. Online ahead of print. PMID: 34583359.

Endoscopic-guided percutaneous radiofrequency cordotomy. Fonoff ET, de Oliveira YS, Lopez WO, Alho EJ, Lara NA, Teixeira MJ. J Neurosurg. 2010 Sep;113(3):524-7. doi: 10.3171/2010.4.JNS091779. PMID: 20433282.

Intraoperative clinical application of augmented reality in neurosurgery: A systematic review. Contreras López WO, Navarro PA, Crispin S. Clin Neurol Neurosurg. 2019 Feb;177:6-11. doi: 10.1016/j.clineuro.2018.11.018. Epub 2018 Nov 23. PMID: 30579049.

Frame-based stereotactic neurosurgery in children under the age of seven: Freiburg University’s experience from 99 consecutive cases. Furlanetti LL, Monaco BA, Cordeiro JG, Lopez WO, Trippel M. Clin Neurol Neurosurg. 2015 Mar;130:42-7. doi: 10.1016/j.clineuro.2014.12.011. Epub 2014 Dec 30. PMID: 25576884.

Clinical and radiological association with positive lumbar discography in patients with chronic low back pain. López WO, Vialle EN, Anillo CC, Guzmao M, Vialle LR. Evid Based Spine Care J. 2012 Feb;3(1):27-34. doi: 10.1055/s-0031-1298598. PMID: 23236303 Free PMC article.

Stereotactic planning software for human neurotransplantation: suitability in 22 surgical cases of Huntington’s disease. Lopez WO, Nikkhah G, Schültke E, Furlanetti L, Trippel M. Restor Neurol Neurosci. 2014;32(2):259-68. doi: 10.3233/RNN-130340. PMID: 24164802.

Listenmee and Listenmee smartphone application: synchronizing walking to rhythmic auditory cues to improve gait in Parkinson’s disease. Lopez WO, Higuera CA, Fonoff ET, Souza Cde O, Albicker U, Martinez JA. Hum Mov Sci. 2014 Oct;37:147-56. doi: 10.1016/j.humov.2014.08.001. Epub 2014 Sep 14. PMID: 25215623.

Parallel improvement in anxiety and tics after DBS for medically intractable Tourette syndrome: A long-term follow-up. Cury RG, Lopez WO, Dos Santos Ghilardi MG, Barbosa DC, Barbosa ER, Teixeira MJ, Fonoff ET. Clin Neurol Neurosurg. 2016 May;144:33-5. doi: 10.1016/j.clineuro.2016.02.030. Epub 2016 Mar 7. PMID: 26963088.

Effects of sexed semen and interactive effects on commercial in vitro embryo production when oocytes are collected from cows of Bos indicus, and Bos taurus breeding and crossbred cows of these subspecies. Lopez WO, Alvis-Miranda HR, Gamarra AF, Rendon B, Borda DA, Albicker U, Fonoff ET, Martinez-Diaz M. Anim Reprod Sci. 2015 May;156:58-63. doi: 10.1016/j.anireprosci.2015.02.009. Epub 2015 Mar 9. PMID: 25796323.

Deep brain stimulation of the globus pallidus internus or ventralis intermedius nucleus of thalamus for Holmes tremor. Espinoza Martinez JA, Arango GJ, Fonoff ET, Reithmeier T, Escobar OA, Furlanetti L, Alvarez Berastegui GR, Fernandes da Silva FE, Contreras Lopez WO. Neurosurg Rev. 2015 Oct;38(4):753-63. doi: 10.1007/s10143-015-0636-0. Epub 2015 May 20. PMID: 25990341.

Intrathecal morphine therapy in the management of status dystonicus in neurodegeneration brain iron accumulation type 1. Lopez WO, Kluge Schroeder H, Santana Neville I, Jacobsen Teixeira M, Costa Barbosa D, Assumpçao de Mônaco B, Talamoni Fonoff E. Pediatr Neurosurg. 2015;50(2):94-8. doi: 10.1159/000370005. Epub 2015 Apr 17. PMID: 25896138.

Caudal Zona Incerta/VOP Radiofrequency Lesioning Guided by Combined Stereotactic MRI and Microelectrode Recording for Posttraumatic Midbrain Resting-Kinetic Tremor. Contreras Lopez WO, Azevedo AR, Cury RG, Alencar F, Neville IS, Reis PR, Navarro J, Monaco B, da Silva FE, Teixeira MJ, Fonoff ET. World Neurosurg. 2016 Feb;86:316-20. doi: 10.1016/j.wneu.2015.09.031. Epub 2015 Sep 28. PMID: 26416091.

Seizure frequency reduction after posteromedial hypothalamus deep brain stimulation in drug-resistant epilepsy associated with intractable aggressive behavior. Benedetti-Isaac JC, Torres-Zambrano M, Vargas-Toscano A, Perea-Castro E, Alcalá-Cerra G, Furlanetti LL, Reithmeier T, Tierney TS, Anastasopoulos C, Fonoff ET, Contreras Lopez WO. Epilepsia. 2015 Jul;56(7):1152-61. doi: 10.1111/epi.13025. Epub 2015 Jul 4. PMID: 26146753

Correlation of (18)F-fluoroethyl tyrosine positron-emission tomography uptake values and histomorphological findings by stereotactic serial biopsy in newly diagnosed brain tumors using a refined software tool. Lopez WO, Cordeiro JG, Albicker U, Doostkam S, Nikkhah G, Kirch RD, Trippel M, Reithmeier T. Onco Targets Ther. 2015 Dec 17;8:3803-15. doi: 10.2147/OTT.S87126. eCollection 2015. PMID: 26719708 Free PMC article.

Interstitial brachytherapy with iodine-125 seeds for low grade brain stem gliomas in adults: diagnostic and therapeutic intervention in a one-step procedure. Lopez WO, Trippel M, Doostkam S, Reithmeier T. Clin Neurol Neurosurg. 2013 Aug;115(8):1451-6. doi: 10.1016/j.clineuro.2013.01.012. Epub 2013 Mar 7. PMID: 23465328.

Directional Deep Brain Stimulation of the Posteromedial Hypothalamus for Refractory Intermittent Explosive Disorder: A Case Series Using a Novel Neurostimulation Device and Intraoperative Microdialysis. Contreras Lopez WO, Navarro PA, Gouveia FV, Fonoff ET, Lebrun I, Auada AVV, Lopes Alho EJ, Martinez RCR. World Neurosurg. 2021 Nov;155:e19-e33. doi: 10.1016/j.wneu.2021.07.086. Epub 2021 Jul 26. PMID: 34325026.

Identification of potential natural neuroprotective molecules for Parkinson’s disease by using chemoinformatics and molecular docking. Rondón-Villarreal P, López WOC. J Mol Graph Model. 2020 Jun;97:107547. doi: 10.1016/j.jmgm.2020.107547. Epub 2020 Jan 24. PMID: 32028110.

Pulsed Radiofrequency Versus Continuous Radiofrequency for Facet Joint Low Back Pain: A Systematic Review. Contreras Lopez WO, Navarro PA, Vargas MD, Alape E, Camacho Lopez PA. World Neurosurg. 2019 Feb;122:390-396. doi: 10.1016/j.wneu.2018.10.191. Epub 2018 Nov 4. PMID: 30404055.

Endoscopic approaches to the spinal cord. Fonoff ET, Lopez WO, de Oliveira YS, Lara NA, Teixeira MJ. Acta Neurochir Suppl. 2011;108:75-84. doi: 10.1007/978-3-211-99370-5_12. PMID: 21107941.

Mystery Case: Brown-Séquard syndrome caused by idiopathic spinal cord herniation. Fonoff ET, Contreras Lopez WO, Teixeira MJ. Neurology. 2016 Jul 26;87(4):e34-5. doi: 10.1212/WNL. 02886. PMID: 27462042.

Microendoscopy-guided percutaneous cordotomy for intractable pain: case series of 24 patients. Fonoff ET, Lopez WO, de Oliveira YS, Teixeira MJ. J Neurosurg. 2016 Feb;124(2):389-96. doi: 10.3171/2014.12.JNS141616. Epub 2015 Jul 31. PMID: 26230468

Sciatica due to heterotopic ossification: case illustration. Lopez WO, Vialle EN, Barbosa DC, Vialle LR. J Neurosurg Spine. 2015 Feb;22(2):192-3. doi: 10.3171/2014.10.SPINE14221. Epub 2014 Dec 5. PMID: 25478821.

Simultaneous bilateral stereotactic procedure for deep brain stimulation implants: a significant step for reducing operation time. Fonoff ET, Azevedo A, Angelos JS, Martinez RC, Navarro J, Reis PR, Sepulveda ME, Cury RG, Ghilardi MG, Teixeira MJ, Lopez WO. J Neurosurg. 2016 Jul;125(1):85-9. doi: 10.3171/2015.7.JNS151026. Epub 2015 Dec 18. PMID: 26684776 Clinical Trial.

Embryonic stem cells in neurology – current clinical transplantation trials in Parkinson’s (PD) and Huntington’s (HD) disease. Lopez WO, Nikkhah G, Maciaczyk J. Arq Neuropsiquiatr. 2014 Dec;72(12):978-9. doi: 10.1590/0004-282X20140154. PMID: 25517648.

Optical coherence tomography imaging of the basal ganglia: feasibility and brief review. Lopez WO, Ângelos JS, Martinez RC, Takimura CK, Teixeira MJ, Lemos Neto PA, Fonoff  ET.Braz J Med Biol Res. 2015 Dec;48(12):1156-9. doi: 10.1590/1414-431X20154679.  Epub  2015  Sep  29.PMID: 26421868 Free  PMC article.Review.

Aesthetically optimal deep brain stimulation technique in patients with alopecia. Fonoff ET, Teixeira MJ, Nascimento CN, LopezWO.Neurocirugia (Astur). 2015 Jul-Aug;26(4):206-8. doi: 10.1016/j.neucir.2015.02.004. Epub 2015 Apr 8.PMID: 25861896.

Bilateral striatal lesion due to herpesvirus-6 infection. Cury RG, Lopez WO.J Neurol Sci. 2015 Nov 15;358(1-2):538-9. doi: 10.1016/j.jns.2015.10.015. Epub 2015 Oct 9.PMID: 26474793 No abstract available.

Pain Relief in CRPS-II after Spinal Cord and Motor Cortex Simultaneous Dual Stimulation. Lopez WO, Barbosa DC, Teixera MJ, Paiz M, Moura L, Monaco BA, Fonoff ET.Pain Physician. 2016 May;19(4):E631-5.PMID: 27228530

Bevacizumab as salvage therapy for progressive brain stem gliomas. Reithmeier T, Lopez WO, Spehl TS, Nguyen T, Mader I, Nikkhah G, Pinsker MO.Clin Neurol Neurosurg. 2013 Feb;115(2):165-9. doi: 10.1016/j.clineuro.2012.04.027. Epub 2012 May 29.PMID: 22652237

Intraindividual comparison of histopathological diagnosis obtained by stereotactic serial biopsy to open surgical resection specimen in patients with intracranial tumours. Reithmeier T, Lopez WO, Doostkam S, Machein MR, Pinsker MO, Trippel M, Nikkhah G.Clin Neurol Neurosurg. 2013 Oct;115(10):1955-60. doi: 10.1016/j.clineuro.2013.05.019. Epub 2013 Jun 14.PMID: 23769864

Stereotactic Gamma Ray Radiosurgery to the Centromedian and Parafascicular Complex of the Thalamus for Trigeminal Neuralgia and Other Complex Pain Syndromes. Lovo EE, Torres B, Campos F, Caceros V, Reyes WA, Barahona KC, Cruz C, Arias J, Alho E, Contreras WO.Cureus. 2019 Dec 19;11(12):e6421. doi: 10.7759/cureus.6421.PMID: 31886103 Free PMC article.

Multiplatform Radiosurgery for Intracranial Meningiomas and Dose to the Dural Tail. Lovo EE, Moreira A, Navarro PA, Barahona KC, Campos F, Caceros V, Blanco A, Arguello-Méndez J, Arce L, Contreras WO.Cureus. 2021 Jan 13;13(1):e12683. doi: 10.7759/cureus.12683.PMID: 33604217 Free PMC article.

Anatomical study on the relationship between the dorsal root ganglion and the intervertebral disc in the lumbar spine. Vialle E, Vialle LR, ContrerasW, Jacob C Junior.Rev Bras Ortop. 2015 Jul 3;50(4):450-4. doi: 10.1016/j.rboe.2015.06.013. eCollection 2015 Jul-Aug.PMID: 26401504 Free PMC article.

Spinal cord stimulation improves gait in patients with Parkinson’s disease previously treated with deep brain stimulation. Pinto de Souza C, Hamani C, Oliveira Souza C, Lopez Contreras WO, Dos Santos Ghilardi MG, Cury RG, Reis Barbosa E, Jacobsen Teixeira M, Talamoni Fonoff E. Mov Disord. 2017 Feb;32(2):278-282. doi: 10.1002/mds.26850. Epub 2016 Nov 10. PMID: 27862267 Clinical Trial.

Long-term comparative outcomes of functional neurosurgical procedures for treatment of secondary hemidystonia WO Lopez, ARC Azevedo, MG Guilardi. Abstracts of the Fifth Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress. Mov Disord. 2016 Mar;31 Suppl 1:S1-103. doi: 10.1002/mds.26577. PMID: 26975800.

Effectiveness and micro-electrodes findings of deep brain stimulation of the STN via a parietal approach in post-infectious previously implanted Parkinson’s patients WO LOPEZ, L Batista, A Azevedo, MJ Teixeira, Fonoff ET. Abstracts of the Fifth Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress. Mov Disord. 2016 Mar;31 Suppl 1:S1-103. doi: 10.1002/mds.26577. PMID: 26975800.

A ying and yang brain. Lopez WO, Paternina JJ, Tierney T. QJM. 2015 Sep;108(9):741-2. doi: 10.1093/qjmed/hcv041. Epub 2015 Feb 5. PMID: 25660610.

Smartphone Application to Improve Gait in Parkinson’s Disease. William Omar Contreras Lopez, Jairo Alberto Espinoza Martinez, Carlos Andres Escalante Higuera. Abstracts of the 2014 Biennial Meeting of the American Society for Stereotactic and Functional Neurosurgery, May 31-June 3, 2014, Washington, D.C., USA. Stereotact Funct Neurosurg. 2014;92 Suppl 1:1-75. doi: 10.1159/000363530. Epub 2014 May 27. PMID: 24902536.

Simultaneous Bilateral MER-Guided Stereotactic Implantation of Deep Brain Stimulation Electrodes Abstracts of the 2014 Biennial Meeting of the American Society for Stereotactic and Functional Neurosurgery, May 31-June 3, 2014, Washington, D.C., USA Erich Talamoni Fonoff, William Omar Contreras Lopez, R.C.R Martinez, Jairo Angelos, A.C. Azevedo, Jessie Navarro, Manoel Jacobsen Teixeira. Stereotact Funct Neurosurg. 2014;92 Suppl 1:1-75. doi: 10.1159/000363530. Epub 2014 May 27. PMID: 24902536.

Model-Based and Mirrored Coordinates for Optimal Spatial Distribution of Intrastriatal Neural Grafts. Abstracts of the 2014 Biennial Meeting of the American Society for Stereotactic and Functional Neurosurgery, May 31-June 3, 2014, Washington, D.C., USA. Stereotact Funct

Neurosurg. 2014; William Omar Contreras Lopez, Guido Nikkhah, Elisabeth Schültke, Luciano Furlanetti, Michael Trippel. 92 Suppl 1:55. doi: 10.1159/000363530. Epub 2014 May 27. PMID: 24902536.

Characteristic activity pattern obtained by MER to demarcate the borders between the caudal zona incerta and STN for stereotactic treatment of post-traumatic tremor. Abstracts of the Eighteenth International Congress of Parkinson’s Disease and Movement Disorders. June 8-12, 2014, Stockholm, Sweden. ET Fonoff, WO LOPEZ, PR Reis, I Neville, J Navarro, Jacobsen MT. Mov Disord. 2014 May;29 Suppl 1: S415. doi: 10.1002/mds.25914. PMID: 24905793.

Practical Use of a portable Auditory Device to improve Freezing of Gait in a patient with Parkinson’s Disease. Abstracts of the 16th Quadrennial Meeting of the World Society for Stereotactic and Functional Neurosurgery. Tokyo, Japan. May 27–30, 2013. William O. Contreras Lopez, Jairo Alberto Espinoza Martinez, Carlos Andres Escalante Higuera. Stereotact Funct Neurosurg. 2013;91 Suppl 1:183. PMID: 23705136.

Atlas-base Coordinates of Targets for Stereotactic Bilateral Neural Transplantation. Abstracts of the 16th Quadrennial Meeting of the World Society for Stereotactic and Functional Neurosurgery. Tokyo, Japan. May 27–30, 2013. William O. Contreras Lopez, Michael Trippel. Stereotact Funct Neurosurg. 2013;91 Suppl 1:213. PMID: 23705136.

Double-target DBS for essential tremor: 8-contact lead for cZI and Vim aligned in the same trajectory. Dos Santos Ghilardi MG, Ibarra M, Alho EJL, Reis PR, Lopez Contreras WO, Hamani C, Fonoff ET. Neurology. 2018 Mar 6;90(10):476-478. doi: 10.1212/WNL.05076. Epub 2018 Feb 7. PMID: 29438045.

Widening possibilities in DBS for essential tremor: 8-contact-lead for cZI and vin aligned in the same trajectory. 17th Quadrennial Meeting of the World Society for Stereotactic and Functional Neurosurgery. Berlin, Germany, June 26-29, 2017. Dos Santos Ghilardi Maria Gabriela, Melisa Ibarra, Paul Rodrigo Reis, William Omar Lopez Contreras, Armando Alaninos, Clement Hamani, Erich Fonoff. Stereotact Funct Neurosurg. 2017 Jun 22;95 Suppl 1:1-460. doi: 10.1159/000478281. Epub ahead of print. PMID: 28641280.

Evaluation and treatment of dystonia: case series of 101 patients. Abstracts of the XXth Congress of the European Society for Stereotactic and Functional Neurosurgery. Lisbon, Portugal. September 26-29, 2012. Contreras Lopez, W.O; Pinsker, M; Arango, G; Escobar; Nikkhah; Espinoza. J. Stereotact Funct Neurosurg. 2012;90 Suppl 156. doi: 10.1159/000342226. PMID: 23018450.

Practical use of an auditory device to improve gait in patients with Parkinson’s disease. Abstracts of the XXth Congress of the European Society for Stereotactic and Functional Neurosurgery. Lisbon, Portugal. September 26-29, 2012. Contreras Lopez, WO; Espinoza Martinez, JA; Escalante Higuera, CA. J. Stereotact Funct Neurosurg. 2012;90 Suppl 22 . doi: 10.1159/000342226. PMID: 23018450.

3-D Position of STN in T2 weighted MR images compared to Stereotactic Atlases for functional neurosurgery planning. Abstracts from the XXIst Congress of the European Society for Stereotactic and Functional Neurosurgery. Implementing Research in Clinical Applications, September 17-20, 2014, Maastricht, The Netherlands. Erich Talamoni Fonoff, William Omar Contreras Lopez. Stereotact Funct Neurosurg. 2014;92 Suppl 2:238. doi: 10.1159/000367644. Epub 2014 Sep 16. PMID: 25247733.